Amhara Region Heath Atlas 2021, presents key results from EPHI and IHME collaborative subnational burden of disease analysis as part of the Global Burden of Disease Study 2019 for Amhara, a region of Ethiopia.  All-cause mortality in Amhara reduced from about 2,370 per 100,000 persons in 1990 to about 955 per 100,000 persons in 2019. The number of DALYs has significantly reduced from about 20 million DALYs in 1990 to 8 million in 2019. Total fertility declined from 6.8 births per woman in 1990 to 3.9 births per woman in 2019, a 43% change. Of the leading causes of YLLs and YLDs in Amhara in 2019, Diarrheal diseases, Neonatal encephalopathy due to birth asphyxia and trauma and Lower respiratory infections are the leading three causes. Child and maternal malnutrition is the source of the greatest number of attributable DALYs, followed by Air pollution. The life expectancy in Amhara region increased from 46 years in 1980 to 69 years in 2019. Amhara region population will live, on average, 61 healthy years, with 9 years lived with disability.