Tigray Region Health Atlas, 2021 presents key results from EPHI and IHME collaborative subnational burden of disease analysis as part of the Global Burden of Disease Study 2019 for Tigray region, a regional state of Ethiopia.  All-cause mortality in Tigray reduced from about 2,560 per 100,000 persons in 1990 to about 983 per 100,000 persons in 2019. The number of DALYs has significantly reduced from about 4,000,000 DALYs in 1990 to 2,000,000 in 2019. Total fertility declined from 6.8 births per woman in 1990 to 3.7 births per woman in 2019, a 46% change. Of the leading causes of YLLs and YLDs in Tigray in 2019, Diarrheal diseases, Lower respiratory infections and Neonatal encephalopathy due to birth asphyxia and trauma are the leading three causes. Child and maternal malnutrition is the source of the greatest number of attributable DALYs, followed by Air pollution mainly from household air pollution. The life expectancy in Tigray increased from 42 years in 1980 to 70 years in 2019. Tigray region population will live, on average, 62 healthy years, with 9 years lived with disability.