Benishangul-Gumuz Health Atlas, 2021 presents key results from EPHI and IHME collaborative subnational burden of disease analysis as part of Global Burden of Disease 2019 Study for Benishangul-Gumuz, a regional state of Ethiopia. All-cause mortality in Benishangul-Gumuz reduced from about 3,260 per 100,000 persons in 1990 to about 1,220 per 100,000 persons in 2019. The number of DALYs has significantly reduced from about 800,000 DALYs in 1990 to 500,000 in 2019. Total fertility declined from 6.8 births per woman in 1990 to 4.3 births per woman in 2019, a 37% change. Of the leading causes of YLLs and YLDs in Benishangul-Gumuz in 2019, Lower respiratory infections, Neonatal encephalopathy due to birth asphyxia and trauma and Diarrheal diseases are the leading three causes. Child and maternal malnutrition is the source of the greatest number of attributable DALYs, followed by Air pollution. The life expectancy in Benishangul-Gumuz increased from 36 years in 1980 to 64 years in 2019. Benishangul-Gumuz region population will live, on average, 56 healthy years, with 8 years lived with disability.